Tesamorelin: The GHRH Analogue for Metabolic and Visceral Adipose Research

ByNuvion Peptides

Tesamorelin (brand name Egrifta) is a synthetic 44-amino-acid analogue of Growth Hormone-Releasing Hormone (GHRH), engineered to resist enzymatic degradation for a more sustained effect. In research it is distinguished by its specific impact on visceral adipose tissue (VAT) — the deep fat around internal organs — making it a primary subject for metabolic-syndrome and lipodystrophy studies.

Mechanism: targeted lipolysis

  1. Pulsatile GH release: like CJC-1295 (No-DAC), triggers a natural pulsatile GH release that preserves endocrine rhythm.
  2. IGF-1 production: increased GH stimulates hepatic IGF-1, mediating growth/repair functions.
  3. Selective lipolysis: reduces visceral fat without significantly affecting subcutaneous fat — by increasing fat oxidation and inhibiting de novo lipogenesis.

Primary research focus areas

  • HIV-associated lipodystrophy: the original, established research area (visceral fat accumulation on long-term antiretroviral therapy).
  • Non-alcoholic fatty liver disease (NAFLD): investigated for reducing liver fat fraction and inflammation.
  • Cognitive health: emerging GH-brain-axis studies on cognition/neuroplasticity in aging models.

Canadian regulatory status

  • Authorized medication: unlike BPC-157 or TB-500, Tesamorelin (as Egrifta) is a Health Canada-approved drug — but strictly for HIV-associated lipodystrophy.
  • Prescription only outside that use; not an OTC natural health product.
  • Research chemicals: tesamorelin sold without prescription is a research chemical — “for research purposes only,” not for human consumption.
  • WADA/CCES: prohibited in and out of competition (S2).

Lab handling & reconstitution

  • Store lyophilized at −20°C; reconstitute with sterile/bacteriostatic water; stable ~24–48h refrigerated at 2–8°C.
  • Precise micro-measurement required to avoid over-stimulating the pituitary.

Browse research-grade Tesamorelin — third-party tested to over 99% purity with a COA.

This guide is part of our Peptides Canada research hub — explore the full library of compound guides.

Note: Educational/research content only. Tesamorelin sold as a research peptide is not for human use.

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