Ipamorelin: The Selective Growth Hormone Secretagogue
Among Growth Hormone Secretagogues (GHS), Ipamorelin is widely regarded as the most refined pentapeptide. As a ghrelin-receptor agonist, it signals the pituitary to release growth hormone (GH). What sets it apart in research is its selectivity — a cleaner profile than earlier GHRPs (GHRP-2/6), making it a standard for studying pulsatile GH secretion without confounding variables.
The molecular advantage: selective signaling
- Selective GH release: even above saturation, it does not significantly raise ACTH or cortisol.
- No prolactin impact: maintains a neutral prolactin profile, keeping observations on the GH/IGF-1 axis.
- Mimics the natural pulse: promotes a GH pulse matching the body’s endogenous rhythm — useful for sleep, metabolic, and protein-synthesis research.
Primary research applications
- Bone mineral density: studied for osteoblast stimulation in osteoporosis models.
- Gastrointestinal motility: ghrelin-receptor action studied for gastric emptying (ileus, gastroparesis).
- Muscle preservation: nitrogen retention and mitigation of muscle wasting in catabolic states.
Ipamorelin + CJC-1295: the synergistic protocol
Frequently paired with CJC-1295 (No-DAC): CJC-1295 (GHRH analogue) increases the amplitude of the GH pulse while Ipamorelin (GHRP) triggers its timing/release — a more robust response than either alone. See our CJC-1295 guide.
Canadian regulatory status
- Not authorized by Health Canada for human use; no DIN.
- Sold strictly for laboratory research only.
- On the WADA Prohibited List (S2) — banned in competitive sport (CCES).
Reconstitution & handling
- Delicate pentapeptide — store lyophilized at −20°C; refrigerate at 2–8°C after reconstitution with bacteriostatic water.
- Avoid excessive agitation and direct sunlight to prevent degradation.
Browse research-grade Ipamorelin and CJC-1295 DAC — tested to over 99% purity with a COA.
This guide is part of our Peptides Canada research hub — explore the full library of compound guides.
Disclaimer: Educational/research content only. Ipamorelin is a research chemical, not for human or animal consumption.