CJC-1295: The GHRH Analogue and Pulsatile Secretion Research
Among growth-hormone (GH) secretagogues, CJC-1295 is one of the most significant synthetic analogues of Growth Hormone-Releasing Hormone (GHRH). It stimulates the pituitary gland, making it a primary subject for research into metabolic regulation, muscle-tissue preservation, and endocrine signaling.
The two variants: DAC vs No-DAC
CJC-1295 with DAC
The DAC (Drug Affinity Complex) version binds albumin in the bloodstream, extending its half-life to an estimated 6–8 days — used to study sustained GH/IGF-1 elevation.
CJC-1295 No-DAC (Modified GRF 1-29)
Lacks the DAC component; half-life ~30 minutes. Favored to mimic the natural pulsatile GH release seen in deep sleep without pituitary desensitization.
Mechanism of action
- Pituitary stimulation: binds GHRH receptors on somatotrophs, activating the adenylate-cyclase/cAMP pathway to trigger GH release.
- IGF-1 modulation: increased GH output indirectly stimulates hepatic IGF-1, the primary driver of cell growth and repair.
- Fat metabolism: studied for effects on lipid oxidation and nitrogen retention.
The CJC-1295 & Ipamorelin stack
Many research protocols pair CJC-1295 (No-DAC) with Ipamorelin: CJC-1295 acts on GHRH receptors while Ipamorelin acts on ghrelin receptors — together producing a more robust GH pulse for studying HPS-axis dynamics.
Canadian regulatory status
- Not authorized as a drug, supplement, or NHP; no DIN/NPN.
- Sold strictly for laboratory research only (target >98% HPLC purity).
- Prohibited in competitive sport (WADA/CCES, peptide hormones & growth factors).
Lab storage & stability
- Reconstitute with bacteriostatic water; sensitive to heat and agitation.
- Store lyophilized at −20°C; refrigerate at 2–8°C after reconstitution and use within 14 days.
Browse research-grade CJC-1295 DAC and Ipamorelin — third-party tested to over 99% purity with a COA on every lot.
This guide is part of our Peptides Canada research hub — explore the full library of compound guides.
Note: Educational/research content only. CJC-1295 is a research chemical, not for human or animal consumption.