CJC-1295: The GHRH Analogue and Pulsatile Secretion Research
Among growth-hormone (GH) secretagogues, CJC-1295 is one of the most significant synthetic analogues of Growth Hormone-Releasing Hormone (GHRH). It stimulates the pituitary gland, making it a primary subject for research into metabolic regulation, muscle-tissue preservation, and endocrine signaling.
The two variants: DAC vs No-DAC
CJC-1295 with DAC
The DAC (Drug Affinity Complex) version binds albumin in the bloodstream, extending its half-life to an estimated 6–8 days — used to study sustained GH/IGF-1 elevation.
CJC-1295 No-DAC (Modified GRF 1-29)
Lacks the DAC component; half-life ~30 minutes. Favored to mimic the natural pulsatile GH release seen in deep sleep without pituitary desensitization.
Mechanism of action
- Pituitary stimulation: binds GHRH receptors on somatotrophs, activating the adenylate-cyclase/cAMP pathway to trigger GH release.
- IGF-1 modulation: increased GH output indirectly stimulates hepatic IGF-1, the primary driver of cell growth and repair.
- Fat metabolism: studied for effects on lipid oxidation and nitrogen retention.
The CJC-1295 & Ipamorelin stack
Many research protocols pair CJC-1295 (No-DAC) with Ipamorelin: CJC-1295 acts on GHRH receptors while Ipamorelin acts on ghrelin receptors — together producing a more robust GH pulse for studying HPS-axis dynamics.
Canadian regulatory status
- Not authorized as a drug, supplement, or NHP; no DIN/NPN.
- Sold strictly for laboratory research only (target >98% HPLC purity).
- Prohibited in competitive sport (WADA/CCES, peptide hormones & growth factors).
Lab storage & stability
- Reconstitute with bacteriostatic water; sensitive to heat and agitation.
- Store lyophilized at −20°C; refrigerate at 2–8°C after reconstitution and use within 14 days.
Browse research-grade CJC-1295 DAC and Ipamorelin — third-party tested to over 99% purity with a COA on every lot.
This guide is part of our Peptides Canada research hub — explore the full library of compound guides.
Note: Educational/research content only. CJC-1295 is a research chemical, not for human or animal consumption.
Frequently Asked Questions
What is Cjc 1295 Dac Vs No Dac in laboratory research?
Cjc 1295 Dac Vs No Dac is discussed in peer-reviewed preclinical literature for mechanistic and cell-model studies — not for clinical use.
Where can researchers source Cjc 1295 Dac Vs No Dac in Canada?
Nuvion Peptides supplies research compounds within Canada with third-party tested purity and COA per batch.
What purity standard should research peptides meet?
Over 99% purity verified by independent analytical methods with lot-specific COA documentation.
Are these products for human consumption?
No. Products are sold strictly for laboratory and research use only — not for human or veterinary consumption.
